Herpesvirus Structure

•Core. The core consists of a single linear molecule of dsDNA in the form of a torus.

•Capsid. Surrounding the core is an icosahedral capsid with a 100 nm diameter constructed of 162 capsomeres.

•Tegument. Between the capsid and envelope is an amorphous, sometimes asymmetrical, feature named the tegument. It consists of viral enzymes, some of which are needed to take control of the cell's chemical processes and subvert them to virion production, some of which defend against the host cell's immediate responses.

•Envelope. The envelope is the outer layer of the virion and is composed of altered host membrane and a dozen unique viral glycoproteins. They appear in electron micrographs as short spikes embedded in the envelope.

Pathogenesis

•Cytomegalovirus (CMV)
•Epstein Barr Virus (Mononucleosis)
•Roseola Infantum (Exanthem Subitum)
•Zoster Virus
1.Initial: Varicella Zoster Virus (Chicken Pox)
2.Reactivation: Herpes Zoster (Shingles)
•Herpes Simplex Virus
1.Type 1: Oral Herpes
2.Type 2: Genital Herpes

Picture Extracted From: http://stdgen.northwestern.edu/stdgen/bacteria/hhv2/herpes.html