Hepdnaviridae

Sunday, February 1, 2009

Introduction to Herpesviridae

A heterogeneous family of morphologically similar viruses, all of which contain double-stranded DNA and infect humans and a wide variety of other vertebrates as well as some invertebrates, such as oysters.

Human herpesvirus infections are endemic and sexual contact is a significant method of transmission for several including both herpes simplex virus 1 and 2 (HSV-1, HSV-2), also human cytomegalovirus (HHV-5) and likely Karposi's sarcoma herpesvirus (HHV-8).

Infections produce type A inclusion bodies; in many instances, infection may remain latent for many years, even in the presence of specific circulating antibodies. Virions are enveloped, ether sensitive, and vary up to 200 nm in diameter; the nucleocapsids are 100 nm in diameter and of icosahedral symmetry, with 162 capsomeres.

The family is subdivided into three subfamilies Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae.





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